Fragrance is more than something we smell—it is something we can physically experience. Certain aromatic molecules interact not only with the olfactory system but also with sensory ion channels that generate sensations such as coolness, warmth, sharpness, freshness, or tingling. One of the most important of these is TRPM8, commonly known as the cold-menthol receptor. When cooling compounds activate TRPM8, the channel opens, allowing calcium and other ions to flow into sensory neurons and triggering the characteristic sensation of coolness. This is why a fragrance can feel refreshingly cool without changing the actual temperature of the surrounding air. Through mechanisms like these, scent becomes more than aroma; it becomes an atmosphere that can be sensed almost physically, influencing how a space and a moment are experienced. At AMATRIUS, we view fragrance as a tool for consciousness because it has the ability to shape not only what we smell, but also how we feel within an environment. Inspired by the pioneering research of Prof. Dr. Hanns Hatt, whose work continues to deepen our understanding of olfactory neuroscience and sensory perception, we explore fragrance as a bridge between chemistry, biology, and human experience. This article is dedicated to his memory and to a friendship that endures beyond a lifetime. The scientific findings discussed here are based on: Behrendt, H. J., Germann, T., Gillen, C., Hatt, H., & Jostock, R. (2004). Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. British Journal of Pharmacology, 141, 737–745. https://doi.org/10.1038/sj.bjp.0705652.
Why does mint feel cold when the room is not?
16 jul 2026